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Low Testosterone Increases Insulin Sensitivity Especially In Obese Men

Researchers recently provided strong evidence showing obesity and testosterone to be related and why testosterone treatment may be one of the effective ways to deal with excessive weight.

The National Institutes of Health sponsored a study which was aimed at providing more evidence that testosterone played vital role in insulin sensitivity and could help in dealing with diseases such as Type 2 diabetes which is becoming common especially among men. The research also brought to light other aspects such as metabolism, anti-inflammation, and oxidative stress.

testosteroneTwo lead researchers; Paresh Dandona, MD, PhD, renowned Professor at SUNY, chief of diabetes, endocrinology, metabolism, and senior author at Jacobs School of Medicine and Biomedical Sciences at University of Buffalo (UB), and Sandeep Dhindsa, MD, formerly of Jacobs School of Medicine and Biomedical Sciences but currently at Texas Tech University Health Sciences Center provided more proof that testosterone and insulin sensitivity are interrelated.

94 men who had Type 2 diabetes were put under observation for a period of 24 weeks with some receiving treatment while other received false treatment (placebo). Besides low levels of testosterone, the men also had low insulin sensitivity meaning there were more prone to absorbing more glucose into the body system. 44 of the men were given testosterone injection while the remaining were given placebo in a randomly-performed experiment.

Dandona and Dhindsa focused more on the insulin sensitization, oxidative stress, and anti-inflammation where it was discovered that testosterone increases muscle while reducing adipose tissue. It was also observed that the level of inflammation and oxidative stress decreased as the testosterone increased and vice versa, and there was no change in the hemoglobin level (A1C (HbA1c).

After undergoing testosterone treatment, the targeted group experienced a decline in insulin sensitivity that resulted to diminished intake of glucose, while there was minimal change in patients treated with placebo. The conclusion was low testosterone which is common in obese men impedes insulin signaling and causes the body to consume more glucose.

They also discovered that testosterone treatment in men enhanced muscle and skeletal strength, increased bone density, and boosted improved sexual function. Insulin resistance is also associated with inflammation that may lead to chronic diseases such as renal failure, hypogonadism, and liver problems as published in the European Journal of Endocrinology.

Following the study, Dandona and Dhindsa hold the opinion that proper testosterone treatment is key to dealing with insulin sensitivity which is commonplace in Type 2 diabetics, obese individuals, and victims of chronic kidney disease.